USDA Confirms SARS-CoV-2 in Mink in Utah after unusually large numbers of mink died at the farms
USDA Confirms SARS-CoV-2 in Mink in Utah
Washington, D.C., August 17, 2020 -- The United States Department of Agriculture’s (USDA) National Veterinary Services Laboratories (NVSL) today announced the first confirmed cases of SARS-CoV-2 (the virus that causes COVID-19 in humans) in mink at two farms in Utah. These are the first confirmed cases of SARS-CoV-2 in mink in the United States. The affected farms also reported positive cases of COVID-19 in people who had contact with the mink.
After unusually large numbers of mink died at the farms, the Utah Veterinary Diagnostic Laboratory completed necropsies on several of the affected animals. Samples were forwarded and tested presumptive positive for SARS-CoV-2 at the Washington Animal Disease Diagnostic Laboratory. Both laboratories are members of the National Animal Health Laboratory Network. The presumptive positive samples were then sent to NVSL for confirmatory testing.
Mink were known to be susceptible to SARS-CoV-2, as the virus was discovered in mink on multiple farms in the Netherlands. Those affected farms also experienced an increase in mink deaths. Affected mink farms have also been identified in Spain and Denmark. USDA has closely monitored these outbreaks and recently issued a document containing guidance for farmed mink in the United States.
There is currently no evidence that animals, including mink, play a significant role in spreading the virus to humans. Based on the limited information available to date, the risk of animals spreading SARS-CoV-2 to people is considered to be low. More studies are needed to understand how different species may be affected by the virus that causes COVID-19, and whether animals may play a role in the spread of the virus.
NVSL serves as an international reference laboratory and provides expertise and guidance on diagnostic techniques, as well as confirmatory testing for foreign and emerging animal diseases. Such testing is required for certain animal diseases in the U.S. in order to comply with national and international reporting procedures. The World Organisation for Animal Health (OIE) considers SARS-CoV-2 an emerging disease, and therefore USDA must report confirmed U.S. animal infections to the OIE.
USDA announces cases of confirmed SARS-CoV-2 in animals each time it is found in a new species. All confirmed cases in animals in the United States are posted at https://www.aphis.usda.gov/aphis/ourfocus/animalhealth/sa_one_health/sars-cov-2-animals-us.
People with COVID-19 can spread the virus to animals during close contact. It is important for people with suspected or confirmed COVID-19 to avoid contact with pets and other animals to protect them from possible infection.
For more information about COVID-19 and animals and recommendations for animal owners, visit CDC’s COVID-19 and Animals page at https://www.cdc.gov/coronavirus/2019-ncov/daily-life-coping/animals.html.
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Comparative Pathogenesis of Bovine and Porcine Respiratory Coronaviruses in the Animal Host Species and SARS-CoV-2 in Humans
Linda J. Saif, Kwonil Jung Alexander J. McAdam, Editor DOI: 10.1128/JCM.01355-20
REPORT
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2
View ORCID ProfileJianzhong Shi1,*, View ORCID ProfileZhiyuan Wen1,*, View ORCID ProfileGongxun Zhong1,*, View ORCID ProfileHuanliang Yang1,*, View ORCID ProfileChong Wang1,*, View ORCID ProfileBaoying Huang2,*, Renqiang Liu1, Xijun He3, Lei Shuai1, Ziruo Sun1, Yubo Zhao1, View ORCID ProfilePeipei Liu2, Libin Liang1, Pengfei Cui1, Jinliang Wang1, View ORCID ProfileXianfeng Zhang3, Yuntao Guan3, View ORCID ProfileWenjie Tan2, View ORCID ProfileGuizhen Wu2,†, View ORCID ProfileHualan Chen1,†, View ORCID ProfileZhigao Bu1,3,† See all authors and affiliations
Science 29 May 2020: Vol. 368, Issue 6494, pp. 1016-1020 DOI: 10.1126/science.abb7015 Article Figures & Data Info & Metrics eLetters PDF Alternative hosts and model animals The severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) pandemic may have originated in bats, but how it made its way into humans is unknown. Because of its zoonotic origins, SARS-CoV-2 is unlikely to exclusively infect humans, so it would be valuable to have an animal model for drug and vaccine development. Shi et al. tested ferrets, as well as livestock and companion animals of humans, for their susceptibility to SARS-CoV-2 (see the Perspective by Lakdawala and Menachery). The authors found that SARS-CoV-2 infects the upper respiratory tracts of ferrets but is poorly transmissible between individuals. In cats, the virus replicated in the nose and throat and caused inflammatory pathology deeper in the respiratory tract, and airborne transmission did occur between pairs of cats. Dogs appeared not to support viral replication well and had low susceptibility to the virus, and pigs, chickens, and ducks were not susceptible to SARS-CoV-2.
Science, this issue p. 1016; see also p. 942
Abstract
Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection. Additionally, cats are susceptible to airborne transmission. Our study provides insights into the animal models for SARS-CoV-2 and animal management for COVID-19 control.
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In summary, we found that ferrets and cats are highly susceptible to SARS-CoV-2; dogs have low susceptibility; and pigs, chickens, and ducks are not susceptible to the virus. Unlike influenza viruses and the other SARS-coronavirus known to infect humans (SARS-CoV-1), which replicate in both the upper and lower respiratory tract of ferrets (20, 22–24, 26, 27), SARS-CoV-2 replicates only in the nasal turbinate, soft palate, and tonsils of ferrets. SARS-CoV-2 may also replicate in the digestive tract, as viral RNA was detected in the rectal swabs of the virus-infected ferrets, but virus was not detected in lung lobes, even after the ferrets were intratracheally inoculated with the virus. It remains unclear whether the virus causes more severe disease in male ferrets than in female ferrets, as has been observed among humans (13, 28).
Several studies have reported that SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its receptor to enter cells (3, 29–31). ACE2 is mainly expressed in type II pneumocytes and serous epithelial cells of tracheo-bronchial submucosal glands in ferrets (25). Ferrets and cats differ by only two amino acids in the SARS-CoV-2 spike-contacting regions of ACE2 (table S1); therefore, the underlying mechanism that prevents the replication of SARS-CoV-2 in the lower respiratory tract of ferrets remains to be investigated. The fact that SARS-CoV-2 replicates efficiently in the upper respiratory tract of ferrets makes them a candidate animal model for evaluating the efficacy of antiviral drugs or vaccines against COVID-19.
The cats we used in this study were outbred and were susceptible to SARS-CoV-2, which replicated efficiently and was transmissible to naïve cats. Cats in Wuhan have been reported to be seropositive for SARS-CoV-2 (32). Surveillance for SARS-CoV-2 in cats should be considered as an adjunct to elimination of COVID-19 in humans.
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